Hi, I’d like to share some information I came across related to this query.
The answer is yes. :) Creating an online business venture is similar to any other kind of business formation and the founders are required to adhere to specific ecommerce law and taxation. There is a need for you to define the legal structure of your online business. This legal structure and the kind of business activity you will be engaging in will determine the type of tax you will be required to pay.
The following links will be useful.
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For registering and tax id matters in Illinois, Link hidden: Login to view
Hope this helps. :)